- URLBibTeXEndNoteDOIBibSonomyElectromagnetic Fields Generated by the IteraCoil Device Differentiate Mesenchymal Stem Progenitor Cells Into the Osteogenic Lineage. Haroutunian, Gagik Greg; Tsaghikian, Ashot; Fedorova, Elena; Chaurasia, Pratima; Gusella, Gabriele Luca; Mosoian, Arevik (2022). 43(4) 245–256.
@article{Haroutunian_2022,
author = {Haroutunian, Gagik Greg and Tsaghikian, Ashot and Fedorova, Elena and Chaurasia, Pratima and Gusella, Gabriele Luca and Mosoian, Arevik},
journal = {Bioelectromagnetics},
keywords = {myown},
month = {apr},
number = 4,
pages = {245--256},
publisher = {Wiley},
title = {Electromagnetic Fields Generated by the IteraCoil Device Differentiate Mesenchymal Stem Progenitor Cells Into the Osteogenic Lineage},
volume = 43,
year = 2022
}%0 Journal Article
%1 Haroutunian_2022
%A Haroutunian, Gagik Greg
%A Tsaghikian, Ashot
%A Fedorova, Elena
%A Chaurasia, Pratima
%A Gusella, Gabriele Luca
%A Mosoian, Arevik
%D 2022
%I Wiley
%J Bioelectromagnetics
%N 4
%P 245--256
%R 10.1002/bem.22401
%T Electromagnetic Fields Generated by the IteraCoil Device Differentiate Mesenchymal Stem Progenitor Cells Into the Osteogenic Lineage
%U https://doi.org/10.1002%2Fbem.22401
%V 43 - URLBibTeXEndNoteDOIBibSonomyIncoming Flow Lamination Increases the Efficiency of Aerosolized Medication Delivery to 3D Oral Mucosal Tissue Models. Haroutunian, G. Greg; Tsagikian, Ashot; Fedorova, Elena; Zheng, Haiyan; Gusella, G. Luca; Mosoian, Arevik (2021). 7(5)
@article{GG_2021,
author = {Haroutunian, G. Greg and Tsagikian, Ashot and Fedorova, Elena and Zheng, Haiyan and Gusella, G. Luca and Mosoian, Arevik},
journal = {International Journal of Dentistry and Oral Health},
keywords = {myown},
number = 5,
publisher = {Sci Forschen, Inc.},
title = {Incoming Flow Lamination Increases the Efficiency of Aerosolized Medication Delivery to 3D Oral Mucosal Tissue Models},
volume = 7,
year = 2021
}%0 Journal Article
%1 GG_2021
%A Haroutunian, G. Greg
%A Tsagikian, Ashot
%A Fedorova, Elena
%A Zheng, Haiyan
%A Gusella, G. Luca
%A Mosoian, Arevik
%D 2021
%I Sci Forschen, Inc.
%J International Journal of Dentistry and Oral Health
%N 5
%R 10.16966/2378-7090.372
%T Incoming Flow Lamination Increases the Efficiency of Aerosolized Medication Delivery to 3D Oral Mucosal Tissue Models
%U https://doi.org/10.16966%2F2378-7090.372
%V 7 - URLBibTeXEndNoteDOIBibSonomyNobiletin Reduces Lipid Accumulation in Sebocytes and Inhibits PPAR Delta Activation in Epidermal Tissue Models. Fedorova, Elena; Li, Shiming; Gusella, G. Luca; Mosoian, Arevik (2021). 6(1)
@article{E_2021,
author = {Fedorova, Elena and Li, Shiming and Gusella, G. Luca and Mosoian, Arevik},
journal = {Journal of Clinical and Laboratory Medicine},
keywords = {myown},
number = 1,
publisher = {Sci Forschen, Inc.},
title = {Nobiletin Reduces Lipid Accumulation in Sebocytes and Inhibits PPAR Delta Activation in Epidermal Tissue Models},
volume = 6,
year = 2021
}%0 Journal Article
%1 E_2021
%A Fedorova, Elena
%A Li, Shiming
%A Gusella, G. Luca
%A Mosoian, Arevik
%D 2021
%I Sci Forschen, Inc.
%J Journal of Clinical and Laboratory Medicine
%N 1
%R 10.16966/2572-9578.139
%T Nobiletin Reduces Lipid Accumulation in Sebocytes and Inhibits PPAR Delta Activation in Epidermal Tissue Models
%U https://doi.org/10.16966%2F2572-9578.139
%V 6 - AbstractURLBibTeXEndNoteDOIBibSonomyMultiple Breast Cancer Cell-Lines Derived from a Single Tumor Differ in Their Molecular Characteristics and Tumorigenic Potential. Mosoyan, Goar; Nagi, Chandandeep; Marukian, Svetlana; Teixeira, Avelino; Simonian, Anait; Resnick-Silverman, Lois; DiFeo, Analisa; Johnston, Dean; Reynolds, Sandra R.; Roses, Daniel F.; Mosoian, Arevik (2013). 8(1) 1–14.Background Breast cancer cell lines are widely used tools to investigate breast cancer biology and to develop new therapies. Breast cancer tissue contains molecularly heterogeneous cell populations. Thus, it is important to understand which cell lines best represent the primary tumor and have similarly diverse phenotype. Here, we describe the development of five breast cancer cell lines from a single patient’s breast cancer tissue. We characterize the molecular profiles, tumorigenicity and metastatic ability in vivo of all five cell lines and compare their responsiveness to 4-hydroxytamoxifen (4-OHT) treatment. Methods Five breast cancer cell lines were derived from a single patient’s primary breast cancer tissue. Expression of different antigens including HER2, estrogen receptor (ER), CK8/18, CD44 and CD24 was determined by flow cytometry, western blotting and immunohistochemistry (IHC). In addition, a Fuorescent In Situ Hybridization (FISH) assay for HER2 gene amplification and p53 genotyping was performed on all cell lines. A xenograft model in nude mice was utilized to assess the tumorigenic and metastatic abilities of the breast cancer cells. Results We have isolated, cloned and established five new breast cancer cell lines with different tumorigenicity and metastatic abilities from a single primary breast cancer. Although all the cell lines expressed low levels of ER, their growth was estrogen-independent and all had high-levels of expression of mutated non-functional p53. The HER2 gene was rearranged in all cell lines. Low doses of 4-OHT induced proliferation of these breast cancer cell lines. Conclusions All five breast cancer cell lines have different antigenic expression profiles, tumorigenicity and organ specific metastatic abilities although they derive from a single tumor. None of the studied markers correlated with tumorigenic potential. These new cell lines could serve as a model for detailed genomic and proteomic analyses to identify mechanisms of organ-specific metastasis of breast cancer.
@article{10.1371/journal.pone.0055145,
abstract = {Background Breast cancer cell lines are widely used tools to investigate breast cancer biology and to develop new therapies. Breast cancer tissue contains molecularly heterogeneous cell populations. Thus, it is important to understand which cell lines best represent the primary tumor and have similarly diverse phenotype. Here, we describe the development of five breast cancer cell lines from a single patient’s breast cancer tissue. We characterize the molecular profiles, tumorigenicity and metastatic ability in vivo of all five cell lines and compare their responsiveness to 4-hydroxytamoxifen (4-OHT) treatment. Methods Five breast cancer cell lines were derived from a single patient’s primary breast cancer tissue. Expression of different antigens including HER2, estrogen receptor (ER), CK8/18, CD44 and CD24 was determined by flow cytometry, western blotting and immunohistochemistry (IHC). In addition, a Fuorescent In Situ Hybridization (FISH) assay for HER2 gene amplification and p53 genotyping was performed on all cell lines. A xenograft model in nude mice was utilized to assess the tumorigenic and metastatic abilities of the breast cancer cells. Results We have isolated, cloned and established five new breast cancer cell lines with different tumorigenicity and metastatic abilities from a single primary breast cancer. Although all the cell lines expressed low levels of ER, their growth was estrogen-independent and all had high-levels of expression of mutated non-functional p53. The HER2 gene was rearranged in all cell lines. Low doses of 4-OHT induced proliferation of these breast cancer cell lines. Conclusions All five breast cancer cell lines have different antigenic expression profiles, tumorigenicity and organ specific metastatic abilities although they derive from a single tumor. None of the studied markers correlated with tumorigenic potential. These new cell lines could serve as a model for detailed genomic and proteomic analyses to identify mechanisms of organ-specific metastasis of breast cancer.},
author = {Mosoyan, Goar and Nagi, Chandandeep and Marukian, Svetlana and Teixeira, Avelino and Simonian, Anait and Resnick-Silverman, Lois and DiFeo, Analisa and Johnston, Dean and Reynolds, Sandra R. and Roses, Daniel F. and Mosoian, Arevik},
journal = {PLOS ONE},
keywords = {myown},
month = {01},
number = 1,
pages = {1-14},
publisher = {Public Library of Science},
title = {Multiple Breast Cancer Cell-Lines Derived from a Single Tumor Differ in Their Molecular Characteristics and Tumorigenic Potential},
volume = 8,
year = 2013
}%0 Journal Article
%1 10.1371/journal.pone.0055145
%A Mosoyan, Goar
%A Nagi, Chandandeep
%A Marukian, Svetlana
%A Teixeira, Avelino
%A Simonian, Anait
%A Resnick-Silverman, Lois
%A DiFeo, Analisa
%A Johnston, Dean
%A Reynolds, Sandra R.
%A Roses, Daniel F.
%A Mosoian, Arevik
%D 2013
%I Public Library of Science
%J PLOS ONE
%N 1
%P 1-14
%R 10.1371/journal.pone.0055145
%T Multiple Breast Cancer Cell-Lines Derived from a Single Tumor Differ in Their Molecular Characteristics and Tumorigenic Potential
%U https://doi.org/10.1371/journal.pone.0055145
%V 8
%X Background Breast cancer cell lines are widely used tools to investigate breast cancer biology and to develop new therapies. Breast cancer tissue contains molecularly heterogeneous cell populations. Thus, it is important to understand which cell lines best represent the primary tumor and have similarly diverse phenotype. Here, we describe the development of five breast cancer cell lines from a single patient’s breast cancer tissue. We characterize the molecular profiles, tumorigenicity and metastatic ability in vivo of all five cell lines and compare their responsiveness to 4-hydroxytamoxifen (4-OHT) treatment. Methods Five breast cancer cell lines were derived from a single patient’s primary breast cancer tissue. Expression of different antigens including HER2, estrogen receptor (ER), CK8/18, CD44 and CD24 was determined by flow cytometry, western blotting and immunohistochemistry (IHC). In addition, a Fuorescent In Situ Hybridization (FISH) assay for HER2 gene amplification and p53 genotyping was performed on all cell lines. A xenograft model in nude mice was utilized to assess the tumorigenic and metastatic abilities of the breast cancer cells. Results We have isolated, cloned and established five new breast cancer cell lines with different tumorigenicity and metastatic abilities from a single primary breast cancer. Although all the cell lines expressed low levels of ER, their growth was estrogen-independent and all had high-levels of expression of mutated non-functional p53. The HER2 gene was rearranged in all cell lines. Low doses of 4-OHT induced proliferation of these breast cancer cell lines. Conclusions All five breast cancer cell lines have different antigenic expression profiles, tumorigenicity and organ specific metastatic abilities although they derive from a single tumor. None of the studied markers correlated with tumorigenic potential. These new cell lines could serve as a model for detailed genomic and proteomic analyses to identify mechanisms of organ-specific metastasis of breast cancer.